The 29-year-old, who has only started one Premier League match this term, was replaced by Dejan Lovren 324 seconds after coming on just after the hour mark at Selhurst Park.
He appeared to tweak a muscle in stretching to challenge Eagles captain Luka Milivojevic.
Lallana has been plagued by a persistent thigh problem this season, although he was included in Gareth Southgate’s latest England squad and featured off the bench against Italy on Tuesday.
But another lengthy lay-off could deny him the chance to prove his readiness for Russia 2018.
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